Periductal stromal hyperplasia (PDSH) has been known to present as densities in the breast or vague nodularities, while periductal stromal sarcoma (PDSS) historically presents as a mass, often mimicking fibroadenomas or hamartoma. } }); Stromal mitotic figures are frequent. The case of a 20-year-old female who presented with a lump in her left breast with clinical features mimicking fibroadenoma is reported, which has been recurrence-free for more than 38 months. 2013 Nov;42(11):729-34. A rare biphasic tumour of the breast characterised by a proliferation of sarcomatous spindle cells surrounding rounded tubules and infiltrating the surrounding adipose tissue. Phyllodes Tumor of the Breast Definition Mixed epithelial and stromal/mesenchymal proliferation of breast characterized by increased stromal cellularity and characteristic broad "leaf-like" papillae inserted into cleft-like spaces Alternate/Historical Names Cystosarcoma phyllodes Diagnostic Criteria Usually large and grossly circumscribed. Lakhani SR, Ellis IO, Schnitt SJ, et al. Epub 2015 Jan 22. Tumor size ranged from 2.9 to 5.9 cm (mean 3.0 cm). 2021 Oct 15;11:577227. doi: 10.3389/fonc.2021.577227. } Methods. Introduction: Fibroadenomas (FAs) and phyllodes tumors (PTs) are less prevalent but allied to have malignant transformation in many instances. They account for less than 1% of all breast neoplasms. The mitotic rate is greater than 3 per 10 HPF. } Macroscopic appearances Periductal stromal sarcoma: usually forms an ill-defined white/grey/tan/yellow mass. Periductal stromal tumor (PST) of the breast is a rare fibroepithelial neoplasm with controversial pathogenesis. Immunohistochemistry for CD10, CD34, KIT, GATA3, p63, SOX10, ER, PR, HER2, smooth muscle actin (SMA), beta-catenin, and myogenin was performed as well. [11] All forms of phyllodes tumors are regarded as having malignant potential. if (inputs[i].id.indexOf("btnplay_") == 0) { Liquid-phase Pyrosequencing, 2015 May;23(3):221-4. doi: 10.1177/1066896914567331. Mitotic activity is present. Yt#},2Xb0hO[,fm p0+2O(?Q[zoy9I nQctt j0Q function stop_all_tracks() Accessibility } Periductal stromal tumor (PST) of the breast is a rare fibroepithelial neoplasm with controversial pathogenesis. government site. `Rj0XOD}Ho8ysm7[.v@>fS" g.r1dN"&z $J2S@ @{dSsXA L PMID: 30610048 Abstract Periductal stromal hyperplasia is an exceedingly rare biphasic breast tumor with benign ductal elements and spindle-cell stromal proliferation lacking a phyllodes architecture. Careers. Page views in 2021: 73,206. MeSH according to the latest world health organization classification of breast tumours, periductal stromal tumors (psts) are to be considered as a rare subtype of phyllodes tumors. Lakhani SR, Ellis IO, Schnitt SJ, et al. onfinish: function() { } } Bethesda, MD 20894, Web Policies [4], Phyllodes tumors typically present as a firm, mobile, and palpable mass that is painless in nature. 1, 31 these tumors have inherent recurrence and/or metastatic potential, which varies based on histologic grade.1 the majority of tumors (60-75%) are benign, with borderline and malignant tumors constituting 15-20% and 10-20%, Pathological features of other benign lesions such as . Please enable it to take advantage of the complete set of features! PubMed Search: Phyllodes tumor of the breast[TI] full text[SB] pathology. Microscopic (optional): Sections show a stromal proliferation featuring areas of leaf-like pattern and stromal expansion with moderate cellularity and stromal atypia. It has biphasic morphology with benign ducts and a sarcomatous stroma with no specific clinical or radiologic findings, which makes it difficult to diagnose (1-4).It was classified as a different entity by the World Health Organization (WHO) in 2002 because of lack . }; Federal government websites often end in .gov or .mil. <> 2014 Jul;21(4):500-3. doi: 10.1007/s12282-011-0271-8. Phyllodes Tumor of the Breast Definition Mixed epithelial and stromal/mesenchymal proliferation of breast characterized by increased stromal cellularity and characteristic broad "leaf-like" papillae inserted into cleft-like spaces Alternate/Historical Names Cystosarcoma phyllodes Diagnostic Criteria Usually large and grossly circumscribed It is a challenge to diagnose the phyllodes by conventional trucut biopsy technique. if (flg == 'play') { The tumor measures ____ in maximal dimension and is clear from (specify if < 1 cm ____) / involves the resection margins. 1, 31 these tumors have inherent recurrence and/or metastatic potential, which varies based on histologic grade.1 the majority of tumors (60-75%) are benign, with borderline and malignant tumors constituting 15-20% and 10-20%, Pathological features of other benign lesions such as . Garmin Hrm-pro Compatible Apps, The risk of developing local recurrence or metastases is related to the histologic grade, according to the above-named features. "}}}; for ( var i = 0; i < forms.length; i++ ) { J Periductal stromal sarcoma (PSS) is an extremely rare neoplasm arising in the connective tissue of the breast, specifically from the periductal stroma. Periductal mastitis is most common in younger, reproductive-age women. Periductal stromal tumor: the periductal stromal tumor is an entity that histologically overlaps with malignant phyllodes tumor, the main difference being the absence of leaf-like processes. The stromal cells were positive for CD10 (4/4), CD34 (4/4), KIT (3/4), and SMA (3/4), and negative for GATA3 (0/6), p63 (0/6), SOX10 (0/6), ER (0/4), PR (0/4), HER2 (0/4), nuclear beta-catenin (0/5), and myogenin (0/4). PSS is a distinct, low-grade breast sarcoma with no clinical or radiological specificity. NCI CPTC Antibody Characterization Program. FOIA PubMed Search: Phyllodes tumor of the breast[TI] full text[SB] pathology. J The 3rd edition terminology of 'periductal stromal sarcoma' is revised to 'periductal stromal tumour', akin to the widespread consensus to avoid the use of the term 'cystosarcoma' in the context of phyllodes tumours. Periductal Stromal Sarcoma of the Breast With Liposarcomatous Differentiation: A Case Report With 10-Year Follow-up and Literature Review. Phyllodes tumors. 3, 7 the spindle Periductal stromal hyperplasia (PDSH) has been known to present as densities in the breast or vague nodularities, while periductal stromal sarcoma (PDSS) historically presents as a mass, often mimicking fibroadenomas or hamartoma. Classification of breast lesions is an evolving process . Periductal stromal tumor; bilateral breast cancer; breast cancer. A 45-year-old woman came to our Hospital because of a palpable mass of the right breast. Periductal Stromal Sarcoma of the Breast With Liposarcomatous Differentiation: A Case Report With 10-Year Follow-up and Literature Review. oggfile = pieces[1]; However, we cannot answer medical or research questions or give advice. Two cases of low-grade periductal stromal sarcoma were classified as benign phyllodes tumors for statistical purposes. It is characterized by proliferation of atypical spindle cells . Periductal stromal sarcoma is an extremely rare malignant fibroepithelial tumor of the breast which is characterized by its biphasic histology with benign ductal elements and a sarcomatous stroma . Breast periductal stromal tumor (PDST) is a rare condition and accounts for less than 1% of all breast malignancies. The tumor is largely circumscribed with focally infiltrative borders. Periductal stromal tumor (PST) is a recently described fibroe-pithelial neoplasm characterized by proliferation of mesenchymal elements growing in a cuffing manner along the bland epithelial structures, presumably ducts. An approximately 5-cm mass was palpated in the upper right breast. Despite their rarity, PTs are an important clinical problem due to their . In this study, we describe the case of a 48-year-old female who presented with a palpable mass in the !BBxHHn%$7Kz{?NC'nH3 @ @ /e2;~63xiyItgo;Nwz%gzo[s]XqZ 7(7J!3Oe|9;0b:CoG1)\(yh x+G_VO(WhzeVpRvG^X:S4~Gg%G~&FdZBZR-26##0":bM0jL'-v{mu~Advy%^pEkHD[Q.VnertD_z]5g')8 ^-+K38l~Arixv4^Gla!}Qhr>7V`BivwlltVi& L.O-=P=ldoCsoLD,!="lG1&qiiSBfGy/m~c(@j'$\M$dRjK/=7( Periductal stromal tumor (PST) of the breast is a rare fibroepithelial neoplasm with controversial pathogenesis. An extremely rare entity, the PST is actually classified as a subtype of phyllodes tumor, with specific criteria that are only found upon histological examination of the specimen. It has biphasic morphology with benign ducts and a sarcomatous stroma with no specific clinical or radiologic findings, which makes it difficult to diagnose (1-4).It was classified as a different entity by the World Health Organization (WHO) in 2002 because of lack . Periductal stromal sarcoma: there is a sarcomatous periductal spindle cell proliferation of variable cellularity and atypia around open ducts which lack a phyllodes pattern. Int J Surg Pathol. There are usually multiple nodules, often separated by fat, within infiltration of tumour into the fat. It is unclear whether this tumor belongs to the spectrum of phyllodes tumor or is a separate entity. Imaging Features of Breast Periductal Stromal Tumor: A Case Report. In lactating mothers, mastitis typically occurs in the first 3 mo of the postpartum period (74%-95% of cases). We present a woman aged 50 years who underwent a Tru-cut biopsy for a BI-RADS 4 lesion on her right breast and received a histopathology diagnosis of a fibroadenoma. Disclaimer, National Library of Medicine A woman aged 50 years who underwent a Tru-cut biopsy for a BI-RADS 4 lesion on her right breast and received a histopathology diagnosis of a fibroadenoma and her final diagnosis was a periductal stromal tumor is presented. } 2. 1, 31 these tumors have inherent recurrence and/or metastatic potential, which varies based on histologic grade.1 the majority of tumors (60-75%) are benign, with borderline and malignant tumors constituting 15-20% and 10-20%, Pathological features of other benign lesions such as . Am J Surg Pathol 2003; 27: 343-8. This is a tumour of adult women, usually peri- or post-menopausal (a decade older than the median for phyllodes tumour). 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